| Final 20:58 | | time | | gap | L | | 1. |  England | 3:31.80 | | | 5 | 1. | | | Brodie Williams 54.02s, James Wilby 59.22s, James Guy 51.22s, Tom Dean, 47.34s | | 2. |  Australia | 3:31.88 | | | 4 | 2. | | | Bradley Woodward 54.07s, Zac Stubblety-Cook 59.92s, Matthew Temple 51.03s, Kyle Chalmers 46.86s | | 3. |  Scotland | 3:35.11 | | | 3 | 3. | | | Craig McNally 54.79s, Ross Murdoch 59.59s, Duncan Scott 51.74s, Evan Jones 48.99s | | 4. |  Wales | 3:36.43 | | | 6 | 4. | | | Joe Small 55.02s, Kyle Booth 1:01.12, Lewis-Fraser 52.31s, Matt Richards 47.98s | | 5. |  Jersey | 3:49.71 | | | 2 | 5. | | | Harry Shalamon 56.18s, Robbie Jones 1:04.17, Isaac Dodds 56.50s, Ollie Brehaut 52.86s | | 6. |  Fiji | 3:55.31 | | | 7 | 6. | | | Hansel McCaig 1:00.70, Epeli Rabua 1:05.08, Temafa Yalimaiwai 57.78s, David Young 51.75s | | 7. |  Guernsey | 3:56.27 | | | 1 | 7. | | | Samuel Lowe 1:00.74, Ronny Hallett 1:04.96, Charlie-Joe Hallett 56.15s, Jonathan Beck 54.42s |
| 49 Competitors from 8 Nations. | | World Record: United States (Ryan Murphy, Michael Andrew, Caeleb Dressel, Zach Apple 3:26.78 Tokyo, Japan 1 August 2021 | | Commonwealth Record: Great Britain (Luke Greenbank, Adam Peaty, James Guy, Duncan Scott 3:27.51 Tokyo, Japan 1 August 2021 | | Commonwealth Games Record: Australia (Mitch Larkin, Jake Packard, Grant Irvine, Kyle Chalmers 3:31.04 Gold Coast, Australia 10 April 2018 |
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Heats - Wednesday, 3rd August 11:10 | | Best 8 times advanced to Final. |
| Heat 2 | | time | | gap | L | Rk. | | 2. | England | 3:35.88 | Q | | 4 | 2. | | | Luke Greenbank 54.28s, Greg Butler 1:00.79, Jacob Peters 52.30s, Jacob Whittle, 48.51s | | 4. | Wales | 3L41.62 | Q | | 3 | 4. | | | Liam White 55.54s, Bradley Newman 1:02.67, Tom Carswell 54.78s, Dan Jones, 48.63s | | 5. | Jersey | 3:52.68 | Q | | 6 | 5. | | | Harry Shalamon 56.80s, Robbie Jones 1:05.89, Jack Allan 56.67s, Ollie Brehaut, 53.32s, | | 6. | Fiji | 3:57.43 | Q | | 2 | 6. | | | Hansel McCaig 1:01.37, Epeli Rabua 1:05.67, Temafa Yalimaiwai 58.05s, David Young, 52.34s, | | -. |  Canada | DSQ | | | 5 | -. | | | Javier Acevedo, James Dergousoff, Patrick Hussey, Stephen Calkins | | -. |  Seychelles | DNS | | | 7 | -. |
| Heat 1 | | time | | gap | L | Rk. | | 1. | Australia | 3:34.35 | Q | | 4 | 1. | | | Mitch Larkin 54.46s, Sam Williamson 1:00.15, Cody Simpson 51.49s, William Yang, 48.25s | | 3. | Scotland | 3:40.41 | Q | | 6 | 3. | | | Martyn Walton 55.10s, Craig Benson 1:00.25, Gregor Swinney 54.05s, Stephen Milne, 51.01s | | 7. | Guernsey | 3:59.47 | Q | | 2 | 7. | | | Samuel Lowe 1:00.38, Ronny Hallett 1:06.67, Charlie-Joe Hallett 57.02s, Jonathan Beck 55.40s, | | -. |  South Africa | DNS | | | 5 | -. | | | Andrew Ross, Michael Houlie, Guy Brooks, Clayton Jimmie | | -. |  Singapore | DNS | | | 3 | -. |
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| 1934: Gazell, Burleigh, Puddy (CAN) 3x100yd |
| 1938: Dove, Davies, Taylor (ENG) 3x110yd |
| 1950: Hale, Kendall, Romain (ENG) 3x110yd |
| 1954: Weld, Hawkins, Henricks (AUS) 3x110yd |
| 1958: Chapman, Monckton, Devitt, Gathercole (AUS) 4x110yd |
| 1962: Dickson, O'Brien, Carroll, Berry (AUS) 4x110yd |
| 1966: Gilchrist, Chase, Hutton, Jacks (CAN) 4x110yd |
| 1970: MacDonald, Kasting, Mahony, Kennedy (CAN) |
| 1974: Phillips, Robertson, Pickell, Mahony (CAN) |
| 1978: Sawchuk, Thompson, Smith, Tapp (CAN) |
| 1982: Orbell, Sieben, Brooks, Evans (AUS) |
| 1986: Tewksbury, Davis, Ponting, Baumann (CAN) |
| 1990: Cleveland, Gery, Tewksbury, Ponting (CAN) |
| 1994: Fydler, Rogers, Miller, Dewick (AUS) |
| 1998: Watson, Cowley, Huegill, Klim (AUS) |
| 2002: Welsh, Piper, Huegill, Thorpe (AUS) |
| 2006: Welsh, Rickard, Klim, Sullivan (AUS) |
| 2010: Delaney, Rickard, Huegill, Sullivan (AUS) |
| 2014: Walker-Hebborn, Peaty, Barrett, Brown (ENG) |
| 2018: Larkin, Packard, Irvine, Chalmers (AUS) |
| 2022: Williams, Wilby, Guy, Dean (ENG) |
| . |
