| Final 19:40 | time | gap | L | React. | Butter | Back | Breast | | 1. Brandonn Almeida |  BRA | 4:14.47 | | 2 | 0.68 | 58.88s | 6. | 2:02.16 | 3. | 3:15.91 | 2. | | 2. Luke Reilly |  CAN | 4:16.16 | 1.69 | 3 | 0.79 | 58.40s | 4. | 2:03.54 | 4. | 3:18.50 | 5. | | 3. Max Williamson |  USA | 4:16.91 | 2.44 | 4 | 0.78 | 59.13s | 7. | 2:05.11 | 6. | 3:17.33 | 4. | | 4. Michael Weiss | USA | 4:17.05 | 2.58 | 5 | 0.76 | 57.54s | 1. | 2:01.93 | 2. | 3:16.17 | 3. | | 5. Alec Page | CAN | 4:18.61 | 4.14 | 8 | 0.74 | 58.16s | 3. | 2:06.18 | 7. | 3:20.18 | 7. | | 6. Carlos Omaña |  VEN | 4:19.11 | 4.64 | 7 | 0.70 | 58.64s | 5. | 2:04.01 | 5. | 3:19.68 | 6. | | 7. Tomas Peribonio |  ECU | 4:22.67 | 8.20 | 1 | 0.71 | 1:00.47 | 8. | 2:07.06 | 8. | 3:22.29 | 8. | | -. Thiago Pereira | BRA | DQ | | 6 | | | | | | | |
| World Record: Michael Phelps (USA) 4:03.84, Beijing (CHN), 10.08.2008. | | Pan American Games Record: Thiago Pereira (BRA) 4:11.14, Rio de Janeiro (BRA), 17.07.2007. | | Qualification times. Standard A: 4:35.99, Standard B: 4:52.55. |
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| Final B 19:31 | time | gap | L | React. | Butter | Back | Breast | | 9. Juan Sequera | VEN | 4:24.97 | | 4 | 0.74 | 59.57s | 1. | 2:10.37 | 3. | 3:23.71 | 2. | | 10.Juan Del Pino |  MEX | 4:26.29 | 1.32 | 3 | 0.73 | 1:00.06s | 2. | 2:07.69 | 1. | 3:23.28 | 1. | | 11.Esteban Paz |  ARG | 4:26.83 | 1.86 | 5 | 0.73 | 1:00.50s | 4. | 2:09.32 | 2. | 3:26.58 | 5. | | 12.Christian Bayo |  PUR | 4:27.15 | 2.18 | 6 | 0.79 | 1:00.56s | 5. | 2:11.17 | 6. | 3:28.31 | 7. | | 13.Rafael Alfaro |  ESA | 4:27.40 | 2.43 | 2 | 0.77 | 1:00.27s | 3. | 2:11.80 | 7. | 3:25.44 | 3. | | 14.Matías Lopez |  PAR | 4:27.47 | 2.50 | 7 | 0.72 | 1:01.44s | 6. | 2:10.93 | 5. | 3:26.84 | 6. | | 15.Luis Vega |  CUB | 4:28.18 | 3.21 | 8 | 0.75 | 1:01.48s | 7. | 2:10.40 | 4. | 3:26.24 | 4. | | 16.Esteban Araya |  CRC | 4:33.80 | 8.83 | 1 | 0.76 | 1:01.70s | 8. | 2:12.96 | 8. | 3:30.39 | 8. |
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Heats - Thursday 16.07 10:11 | | First 8 to Final. Next 8 to Final B. |
| Ranking | time | gap | L | React. | Butter | Back | Breast | .Heat | | 1. Max Williamson | USA | 4:17.92 | Q | 5 | 0.79 | 59.30s | 2. | 2:05.89 | 3. | 3:18.16 | 1. | Heat 2 | | 2. Michael Weiss | USA | 4:17.96 | 0.04 | 4 | 0.76 | 58.82s | 1. | 2:05.11 | 1. | 3:18.97 | 2. | Heat 2 | | 3. Luke Reilly | CAN | 4:19.44 | 1.52 | 5 | 0.77 | 59.47s | 1. | 2:04.53 | 2. | 3:20.05 | 2. | Heat 3 | | 4. Thiago Pereira | BRA | 4:19.92 | 2.00 | 4 | 0.80 | 59.59s | 2. | 2:03.75 | 1. | 3:16.57 | 1. | Heat 3 | | 5. Brandonn Almeida | BRA | 4:20.59 | 2.67 | 4 | 0.72 | 59.56s | 3. | 2:02.67 | 1. | 3:18.00 | 1. | Heat 1 | | 6. Carlos Omaña | VEN | 4:20.84 | 2.92 | 3 | 0.69 | 59.61s | 3. | 2:05.55 | 3. | 3:20.65 | 3. | Heat 3 | | 7. Tomas Peribonio | ECU | 4:21.07 | 3.15 | 3 | 0.68 | 59.90s | 4. | 2:05.82 | 2. | 3:21.45 | 3. | Heat 2 | | 8. Alec Page | CAN | 4:21.46 | 3.54 | 5 | 0.74 | 59.33s | 1. | 2:07.13 | 2. | 3:20.97 | 2. | Heat 1 | | to Final B | | 9. Juan Sequera | VEN | 4:25.69 | 7.77 | 3 | 0.68 | 59.43s | 2. | 2:09.20 | 4. | 3:23.70 | 3. | Heat 1 | | 10.Esteban PAZ | ARG | 4:27.37 | 9.45 | 6 | 0.81 | 1:01.22 | 5. | 2:09.05 | 3. | 3:26.40 | 5. | Heat 1 | | 11.Juan Del Pino | MEX | 4:28.37 | 10.45 | 6 | 0.75 | 59.76s | 4. | 2:07.17 | 4. | 3:24.50 | 4. | Heat 3 | | 12.Christian Bayo | PUR | 4:28.54 | 10.62 | 6 | 0.76 | 59.81s | 3. | 2:09.88 | 6. | 3:28.59 | 5. | Heat 2 | | 13.Rafael Alfaro | ESA | 4:29.81 | 11.89 | 2 | 0.76 | 59.94s | 4. | 2:11.60 | 5. | 3:26.37 | 4. | Heat 1 | | 14.Matías Lopez | PAR | 4:30.27 | 12.35 | 7 | 0.71 | 1:00.19 | 6. | 2:08.32 | 5. | 3:24.40 | 4. | Heat 2 | | 15.Esteban Araya | CRC | 4:31.52 | 13.60 | 1 | 0.74 | 1:01.71 | 7. | 2:11.75 | 6. | 3:28.70 | 5. | Heat 3 | | eliminated | | 16.Luis Vega | CUB | 4:32.86 | 14.94 | 2 | 0.79 | 1:01.53 | 6. | 2:11.58 | 5. | 3:29.26 | 6. | Heat 3 | | 17.Felipe Quiroz |  CHI | 4:36.65 | 18.73 | 1 | 0.71 | 1:01.59 | 7. | 2:13.47 | 7. | 3:33.27 | 7. | Heat 2 | | 18.Jean Pierre Monteagudo |  PER | 4:38.75 | 20.83 | 7 | 0.82 | 1:00.63 | 5. | 2:12.89 | 7. | 3:34.31 | 7. | Heat 3 | | 19.Aldo Castillo Sulca |  BOL | 4:58.57 | 40.65 | 1 | 0.73 | 1:02.41 | 6. | 2:19.76 | 6. | 3:47.36 | 6. | Heat 1 | | -. Julio Olvera | MEX | DQ | | 2 | | | | | | | | Heat 2 | | -. Yeziel Morales | PUR | DNS | | 7 | | | | | | | | Heat 1 |
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| Swimmer | Q. time | Birth | | Thiago Pereira | BRA | 4:13.94 | 26 JAN 1986 | | Michael Weiss | USA | 4:14.85 | 23 MAY 1991 | | Brandonn Almeida | BRA | 4:15.82 | 16 MAR 1997 | | Luke Reilly | CAN | 4:15.86 | 23 NOV 1995 | | Max Williamson | USA | 4:17.76 | 20 OCT 1994 | | Alec Page | CAN | 4:19.15 | 08 NOV 1993 | | Carlos Omaña | VEN | 4:21.18 | 08 FEB 1993 | | Tomas Peribonio | ECU | 4:24.28 | 16 JAN 1996 | | Juan Sequera | VEN | 4:24.39 | 12 NOV 1993 | | Juan Del Pino | MEX | 4:26.12 | 20 SEP 1992 | | Christian Bayo | PUR | 4:27.32 | 12 APR 1991 | | Esteban Paz | ARG | 4:27.64 | 22 SEP 1989 | | Luis Vega | CUB | 4:28.09 | 02 NOV 1998 | | Julio Olvera | MEX | 4:29.51 | 19 JUL 1995 | | Rafael Alfaro | ESA | 4:30.24 | 04 FEB 1992 | | Jean Pierre Monteagudo | PER | 4:32.02 | 06 OCT 1997 | | Matías Lopez | PAR | 4:32.58 | 29 JAN 1996 | | Yeziel Morales | PUR | 4:32.60 | 16 JAN 1966 | | Esteban Araya | CRC | 4:34.26 | 15 JUN 1996 | | Standard A: 4:35.99 | | Felipe Quiroz | CHI | 4:38.31 | 13 OCT 1995 | | Aldo Castillo Sulca | BOL | 4:52.30 | 16 AUG 1995 | | Standard B: 4:52.55 |
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