| Final | | date | time | team 1 ____________ | score | team 2 ____________ | HT | att. | | Wed 25.05.22 | 21:00 | AS Roma |  ITA | 1–0 | Feyenord Rotterdam |  NED | 1-0 | 19,597 |  1-0 Zaniolo 32' Arena Kombetare, Tirana, Albania. Referee: Istvan Kovacs, Romania. |
| dates | team 1 ____________ | Leg 1 | Leg 2 | team 2 ____________ | HT1 | HT | aggr. | | 28.04, 05.05 | Leicester City |  ENG | 1-1 | 0-1 | AS Roma | ITA | 0-1 | 0–1 | 1-2 | | 28.04, 05.05 | Feyenord Rotterdam | NED | 3-2 | 0-0 | Olympique Marseille |  FRA | 2–1 | 0–0 | 3-2 |
| dates | team 1 ____________ | Leg 1 | Leg 2 | team 2 ____________ | HT1 | HT | aggr. | | 07.04, 14.04 | Bodo/Glimt |  NOR | 2-1 | 0-4 | AS Roma | ITA | 0-1 | 0-3 | 2-5 | | 07.04, 14.04 | Feyenord Rotterdam | NED | 3-3 | 3-1 | Slavia Prague |  CZE | 1-1 | 1-1 | 6-4 | | 07.04, 14.04 | Olympique Marseille | FRA | 2-1 | 1-0 | PAOK Thessaloniki |  GRE | 2-0 | 1-0 | 3-1 | | 07.04, 14.04 | Leicester City | ENG | 0-0 | 2-1 | PSV Einfhoven | NED | 0-0 | 0-1 | 2-1 |
| dates | team 1 ____________ | Leg 1 | Leg 2 | team 2 ____________ | HT1 | HT2, FT2 | aggr. | | 10.03, 17.03 | Olympique Marseille | FRA | 2-1 | 2-1 | FC Basel |  SUI | 1-0 | 0-0 | 4-2 | | 10.03, 17.03 | Leicester City | ENG | 2-0 | 1-2 | Stade Rennais | FRA | 1-0 | 0-1 | 3-2 | | 10.03, 17.03 | PAOK Thessaloniki | GRE | 1-0 | 2-1 | KAA Gent |  BEL | 0-0 | 1-1 | 3-1 | | 10.03, 17.03 | Vitesse Arnheim | NED | 0-1 | 1-1 | AS Roma | ENG | 0-1 | 0-0 | 1-2 | | 10.03, 17.03 | PSV Eindhoven | NED | 4-4 | 4-0 | FC Copenhagen |  DEN | 1-2 | 2-0 | 8-4 | | 10.03, 17.03 | Slavia Prague | CZE | 4-1 | 3-4 | LASK Linz |  AUT | 2-0 | 2-1 | 7-5 | | 10.03, 17.03 | Bodo/Glimt | NOR | 2-1 | 2-2aet | AZ Alkmaar | NED | 1-0 | 1-1, 1-2 | 4-3aet | | 10.03, 17.03 | Partizan Beograd |  SRB | 2-5 | 1-3 | Feyenord Rotterdam | NED | 1-1 | 0-1 | 3-8 |
| dates | team 1 ____________ | Leg 1 | Leg 2 | team 2 ____________ | HT1 | HT1, FT2 | aggr. | | 17.02, 24.02 | Olympique Marseille | FRA | 3–1 | 3–0 | Qarabag Agdam |  AZE | 2-0 | 1-0 | 6-1 | | 17.02, 24.02 | PSV Eindhoven | NED | 1–0 | 1–1 | Maccabi Tel-Aviv |  ISR | 1-0 | 0-0 | 2-1 | | 17.02, 24.02 | Fenerbahce Istanbul |  TUR | 2–3 | 2–3 | Slavia Prague | CZE | 0-1 | 1-2 | 4-6 | | 17.02, 24.02 | Midtjylland | DEN | 1–0 | 1–23-5p | PAOK Thessaloniki | GRE | 1-0 | 0-2, 1-2 | 2-23-5p | | 17.02, 24.02 | Leicester City | ENG | 4–1 | 3–1 | Randers FC | DEN | 1-1 | 1-0 | 7-2 | | 17.02, 24.02 | Celtic Glasgow |  SCO | 1–3 | 0-2 | Bodo/Glimt | NOR | 0-1 | 0-1 | 1-5 | | 17.02, 24.02 | Sparta Prague | CZE | 0–1 | 1–2 | Partizan Beograd | SRB | 0-0 | 0-2 | 1-3 | | 17.02, 24.02 | Rapid Wien | AUT | 2–1 | 0-2 | Vitesse Arnheim | NED | 2-0 | 0-2 | 2-3 |
|
|
