| Final 10.08 | Team | time | L | Rk. | | 1. Michael Phelps | USA | 4:03.84 | 4 | 1. | | 2. Laszlo Cseh | HUN | 4:06.16 | 5 | 2. | | 3. Ryan Lochte | USA | 4:08.09 | 6 | 4. | | 4. Alessio Boggiatto | ITA | 4:12.16 | 7 | 6. | | 5. Luca Marin | ITA | 4:12.47 | 3 | 3. | | 6. Gergo Kis | HUN | 4:12.84 | 2 | 5. | | 7. Brian Johns | CAN | 4:13.38 | 1 | 7. | | 8. Thiago Pereira | BRA | 4:15.40 | 8 | 8. |
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| Round | H | Athl. | date |
| | Heats | 4 | 29 | 09.08 |
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| Heat 4 09.08 18:50 | Team | time | L | Rk. | | 1. Michael Phelps | USA | 4:07.82 | 4 | 1. | | 2. Luca Marin | ITA | 4:10.22 | 5 | 3. | | 3. Gergo Kis | HUN | 4:10.66 | 3 | 5. | | 4. Keith Beavers | CAN | 4:12.75 | 2 | 9. | | 5. Travis Nederpelt | AUS | 4:15.37 | 6 | 14. | | 6. Vadym Lepskyy | UKR | 4:20.96 | 8 | 20. | | 7. Pierre Henri | FRA | 4:22.41 | 7 | 22. | | 8. Romanos Iasonas Alyfantis | GRE | 4:23.41 | 1 | 25. |
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| Heat 3 09.08 18:44 | Team | time | L | Rk. | | 1. Ryan Lochte | USA | 4:10.33 | 4 | 4. | | 2. Brian Johns | CAN | 4:11.41 | 7 | 7. | | 3. Thiago Pereira | BRA | 4:11.74 | 5 | 8. | | 4. Riaan Schoeman | RSA | 4:14.09 | 3 | 12. | | 5. Andrey Krylov | RUS | 4:14.55 | 1 | 13. | | 6. Euan Dale | GBR | 4:18.60 | 6 | 19. | | 7. Omar Pinzon | COL | 4:22.31 | 8 | 21. | | 8. Javier Nunez | ESP | 4:22.69 | 2 | 24. |
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| Heat 2 09.08 18:39 | Team | time | L | Rk. | | 1. Laszlo Cseh | HUN | 4:09.26 | 4 | 2. | | 2. Alessio Boggiatto | ITA | 4:10.68 | 3 | 6. | | 3. Bradley Ally | BAR | 4:14.01 | 1 | 10. | | 4. Gal Nevo | ISR | 4:14.03 | 8 | 11. | | 5. Dinko Jukic | AUT | 4:15.48 | 2 | 15. | | 6. Alexander Tikhonov | RUS | 4:16.49 | 7 | 16. | | 7. Thomas Haffield | GBR | 4:16.72 | 5 | 17. | | 8. Vasileios Demetis | GRE | 4:18.40 | 6 | 18. |
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| Heat 1 09.08 18:33 | Team | time | L | Rk. | | 1. Niksa Roki | CRO | 4:22.44 | 4 | 23. | | 2. Dmitriy Gordiyenko | KAZ | 4:25.20 | 6 | 26. | | 3. Vasilii Danilov | KGZ | 4:29.20 | 2 | 27. | | 4. Deniz Nazar | TUR | 4:30.80 | 3 | 28. | | 5. Hocine Haciane Constantin | AND | 4:32.00 | 5 | 29. |
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